Multiscale Modeling of the Epithelial-Mesenchymal Transition

Speaker: 

Catherine Ta

Institution: 

University of California, Irvine

Time: 

Tuesday, April 18, 2017 - 4:00pm to 4:50pm

Location: 

RH 340P

Epithelial-mesenchymal transition (EMT) is an instance of cellular plasticity that plays critical roles in development, regeneration and cancer progression. Utilizing a systems biology approach integrating modeling and experiments, we observed that adding the mutual inhibition relationship between Ovol2 and EMT inducer Zeb1 generates a novel four-state system consisting of two distinct intermediate phenotypes that differ in differentiation propensities and are favored in different environmental conditions. We then used mathematical models to show that multiple intermediate phenotypes in the EMT system help to attenuate the overall fluctuations of the cell population in terms of phenotypic compositions, thereby stabilizing a heterogeneous cell population in the EMT spectrum. Lastly, we attempted to bridge the gap between discrete and continuum modeling of the EMT system by incorporating the EMT core regulatory network into our heterogeneous cell population dynamics model to create a multiscale EMT model. Our model can capture the larger-scale population growth dynamics while acknowledging the intracellular interactions between proteins within each individual cell. This talk is aimed at a general audience.

For more information about MGSC: https://www.math.uci.edu/~mgsc/index.php

L^\infty-variation problems and the well-posedness of the viscosity solutions for a class of Aronsson's equations

Speaker: 

Qianyun Miao

Institution: 

Beihang University and UCI

Time: 

Tuesday, April 18, 2017 - 3:00pm

Location: 

RH306

For a bounded domain, we consider the L^\infty-functional involving a nonnegative Hamilton function. Under the continuous Dirichlet boundary condition and some assumptions of Hamiltonian H, the uniqueness of absolute minimizers for Hamiltonian H is established. This extendes the uniqueness theorem to a larger class of Hamiltonian $H(x,p)$ with $x$-dependence. As a corollary, we confirm an open question on the uniqueness of absolute minimizers posed by Jensen-Wang-Yu. Our proofs rely on geometric structure of the action function induced by Hamiltonian H(x,p), and the identification of the absolute subminimality with convexity of the associated Hamilton-Jacobi flow.  

Cryptography Learning Seminar

Speaker: 

Nathan Kaplan

Institution: 

UC Irvine

Time: 

Monday, April 17, 2017 - 3:00pm to 4:00pm

Location: 

RH 440R

Computing the Unit Group of a Number Field

Starting from Pell’s equation and units in real quadratic fields, we will discuss the problem of computing the unit group of a number field. This will lead to a discussion of the Hidden Subgroup Problem, which arises in many quantum algorithms.  We will discuss recent work of Eisentrager, Hallgren, Kitaev, and Song, and of Biasse and Song, giving a quantum algorithm for this problem that runs in polynomial time.

Interacting Polya urns (on joint works with Christian Hirsch and Mark Holmes)

Speaker: 

Victor Kleptsyn

Institution: 

Universite Rennes 1, CNRS

Time: 

Tuesday, April 11, 2017 - 1:00pm to 2:00pm

Host: 

Location: 

RH 440R

In the classical Polya’s urn process, there are balls of different colors in the urn, and one step of the process consists of taking out a random ball and it putting back together with one more ball of the same color. ("Ask a friend whether he’s using is A or B, and buy the same".)

It also can be modified by saying that the reinforcement probability is proportional not to the number of balls of a given color, but to its power $\alpha$, and the asymptotic behaviour for $\alpha=1$, $\alpha>1$ and for $\alpha<1$ are quite different.

The talk will be devoted to the model of interacting urns : at each moment, there is a competition for reinforcement between randomly chosen subset of colours; for a real-life analogue, one can consider companies competing on different markets (one company produces toys and computers, another sells computers and cars, etc.).

We will describe possible types of the limit behaviour of such model for different values of $\alpha$; it turns out that what happens for $\alpha>>1$ is quite different from $\alpha=1$, and both are quite interesting (this is a joint work with Christian Hirsch and Mark Holmes).

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