We are interested in determining the most likely control network(s) that govern the regulation of human colon crypt stem cell lineages, where lineages are comprised of stem cells, transit amplifying cells, and differentiated cells. We started with a theoretically known set of 32 smallest control networks compatible with tissue stability. We proposed and implemented an algorithm of tests where we compared the networks' simulated behavior with the measured observations, and we discovered only 3 candidate networks that are most compatible with the measurements.

See the MGSC website for more details: http://www.math.uci.edu/~mgsc/index.php