Speaker:
Yoichiro Mori
Institution:
University of Minnesota
Time:
Monday, March 16, 2015 - 4:00pm to 5:00pm
Host:
Location:
RH306
Electrolyte and cell volume regulation is essential in physiological systems. After a brief introduction to cell volume control and electrophysiology, I will discuss the classical pump-leak model of electrolyte and cell volume control. I will then generalize this to a PDE model that allows for the modeling of tissue-level electrodiffusive, convective and osmotic phenomena. This model will then be applied to the study of cortical spreading depression, a wave of ionic homeostasis breakdown, that is the basis for migraine aura and other brain pathologies.