I will present a systematic approach to develop models for biofilm and solvent mixture. Models at various time and length scales will be introduced.
Quorum sensing, cell adhesion, and other cellular movement due to chemotaxis and haptotaxis will be discussed. Biofilm growth and interaction with the ambient flow
in an infinitely long channel and a finite length flow chamber will be simulated using a 3-D numerical simulation tool developed based on the models. The role of antimicrobial agents
will be investigated as well.