Our research focus on the mathematical modeling and numerical simulations of vascular tumor growth and chemotherapy. We have developed a model by coupling a discrete angiogenesis model and a continuous tumor growth model accounting for vascular and interstitial fluid dynamics (vascular flow, vascular fluid extravasation, interstitial fluid flow and lymphatic drainage), which affects the delivery of nutrients and therapeutical agents during tumor growth/treatment. The talk will discuss over (1) overview of vascular tumor growth, (2) the tumor vascular/interstitial pressure/flow and the related physiological factors, (3) traditional drug transportation, chemotherapy and the physical barrier therein (4) the novel treatment strategy.