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Curriculum Vitae of Vittorio Cristini, Ph.D., F.A.A.N.

EDUCATION

· Ph.D. Chemical Engineering 2000, Yale U.; thesis: “Drop dynamics in viscous flow”

· M. Phil. Chemical Engineering 1998, Yale U.

· M. S. Chemical Engineering 1996, Yale U.

· Laurea Summa-Cum-Laude Nuclear Engineering 1994, U. of Rome “La Sapienza”

APPOINTMENTS AND PROFESSIONAL ORGANIZATIONS SERVICE

· Associate Professor, School of Health Information Sciences, U. of Texas Health Sciences Center at Houston, Dec. 2006-

· Associate Professor, Department of Mathematics, U. C. Irvine, 2006-2007

· Assistant Professor, Department of Biomedical Engineering, U. C. Irvine, Sept. 2002-Dec 2006

· Assistant Professor, Department of Mathematics, U. C. Irvine, 2003-Dec. 2006

· Visiting Assistant Professor of Chemical Engineering, U. of Naples, Italy, Aug.-Sept. 2005

· Visiting Assistant Professor, School of Mathematics, U. of Minnesota, 2002

· Postdoctoral Associate, Institute for Mathematics and its Applications, U. of Minnesota, 2001-2002

· Postdoctoral Associate, Chemical Engineering and Materials Science, U. of Minnesota, 2000-2002

· Board of Directors, International Brain Mapping and Intra-operative Surgical Planning Society, 2004-present

· Chief Financial Officer, International Brain Mapping and Intra-operative Surgical Planning Foundation, 2006-

· Scientific Advisory Board, Centre for Molecular (Bio)Medicine, Trieste, Italy, 2005-present

· Fluids Programming Committee Member, American Institute of Chemical Engineers (AIChE), 2004-present.

· President and Co-Founder, Advanced Biomedical Technologies, LLC

· Co-Founder, Mathematical and Computational Biology Graduate Program, UC Irvine, 2003-present.

· Mentor Faculty, National Inst of Health-National Inst of Dental and Craniofacial Res, T32 Training Grant, Univ/Minnesota 02.

EDITORIAL WORK

· Guest Editor, NeuroImage (Elsevier), 2006-2007

· Editor, Biomedical Microdevices (Springer), 2004-present

· Editor, J. of Biomedical Nanotechnology (American Scientific Publishers), 2004-present

AWARDS, HONORS AND CITATIONS

· Fellow, American Academy of Nanomedicine, 2006-present

· New Hot Paper in the field of Mathematics, July, 2006, Thomson-Scientific Essential Science Indicators (Zheng et al., Bull Math Biol 2005;67(2):211-59.)

· Cancer Research Highlights, Feb 1 2006: “Simulation model predicts tumor invasion in marginal environmental conditions.” (Frieboes et al., Cancer Res 2006;66(3):1597-604.)

· UNCF-MERCK Graduate Science Research Dissertation Fellowship, 2006-2008 (Student: N DeMagalhaes).

· Physical Sciences Faculty Endowed Award, U.C. Irvine, 2003-4 (Student: X. Zheng,)

· B. S. Honors Thesis, U. of Minnesota 2004 (Student: A. Anderson)

· Research Scholarship, Minnesota Supercomputing Institute, U. of Minnesota 2001

· Andreas Acrivos Dissertation Award in Fluid Dynamics, American Physical Society—Division of Fluid Dynamics 2000, “For important theoretical and numerical contributions to the description and understanding of drop dynamics and breakup in laminar and turbulent flows”

· Henry Prentiss Becton Dissertation Award, Yale U. 2000, “For exceptional achievements in the field of Engineering and Applied Science”

· Outstanding Paper Award, American Institute of Chemical Engineers 1997

· Harold Cheel Fund Graduate Fellowship, Yale U. 1995

· Top 0.7 percentile of citations, Lab on a Chip 2004-present. (Tan et al., Lab on a Chip 2004;4(4):292-8)

· Top 0.4 percentile of citations, J. of Computational Physics 2001-present. (Cristini et al., J. Comp Phys 2001;168(2):445-63.)

· Top 0.5 percentile of citations, Physics of Fluids 1998-present. (Cristini et al., Phys Fluids 1998;10(8):1781-3.)

· Most cited article, Bulletin of Mathematical Biology 2005-present. (Zheng et al., Bull Math Biol 2005;67(2):211-59.)

· Most cited article, J of Mathematical Biology 2003-present. (Cristini et al., J. of Math Biol 2003;46(3):191-224.)

TRAINEES GRADUATED

· Nzola DeMagalhaes, Ph.D. Biomedical Engineering, U.C. Irvine 2007 (expected)

· Sandeep Sanga, Ph.D. Biomedical Engineering, U.T. Austin/Houston 2007 (expected)

· Xiangrong Li, Ph.D. Applied Mathematics, U.C. Irvine, 2007 (expected; not primary advisor)

· Paul Macklin, Ph.D. Applied Mathematics, U.C. Irvine, 2006 (expected; not primary advisor)

· Hermann Frieboes, Ph.D. Biomedical Engineering, U.C. Irvine 2006

· John Sinek, Ph.D. Applied Mathematics, U.C. Irvine, 2005

· Xiaoming Zheng, Ph.D. Applied Math, U.C. I., 2005 (Physical Sciences Faculty Endowed Award, 2003-4)

· Shuwang Li, Ph.D. Aerospace Engineering and Mechanics, U. of Minnesota 2005 (not primary advisor)

· Kaveh Azartash, M.S. Biomedical Engineering, U.C. Irvine, 2006

· Ryan Hainley, M.S. Biomedical Engineering, U.C. Irvine 2005

· Balakrishnan Sivaraman, M.S. Chemical Engineering and Materials Science, U.C. Irvine 2005

· Anthony Anderson, B.S. Chemical Eng and Materials Science, U. of Minnesota 2004 (Honors Thesis)

RESEARCH FUNDING

· National Science Foundation—Mathematical Sciences PI (2003-2007), “Collaborative Research: Analysis and properties of co-continuous blends-A numerical and experimental investigation,” $132,000.

· National Science Foundation—Materials MRSEC Program Co-PI (2003-2004), “Analysis and 3D simulations of quantum-dot formation on patterned substrates,” $62,000.

· ORQIS Medical PI (2004), “CFD analysis for the treatment of congestive heart failure,” $4,000.

· National Institutes for Health—National Cancer Institute Co-PI (2005-2007), “Multidisciplinary studies of tumor vascularity and microenvironment,” $60,000.

· U.C. Discovery—IT for life sciences/ ORQIS Medical PI (2005-2007), “Analysis and Optimization of Blood Circuit Components Using Adaptive CFD,” $188,000.

· UNCF-MERCK Graduate Science Research Dissertation Fellowship PI (2007-2009), “An integrated biological and computational tumor model,” $52,000 (Student: N DeMagalhaes).

· U. C. Irvine, Center for Complex Biological Systems Seed Grant PI (2003-2004), “Computational and Experimental Modeling of Tumor Spheroid Growth and Photodynamic Therapy: A First Step Towards an In Vivo Model,” $11,000.

· U. C. Irvine, Biomedical Engineering/College of Medicine Seed Grant PI (2003-2004), “Modeling breast tumor morphology to predict drug response,” $15,000.

PEER-REVIEWED PUBLICATIONS (45 TOTAL)

CANCER AND NANOTECHNOLOGY

Journal Articles

J1. H. Frieboes, X. Zheng, C.-H. Sun, B. Tromberg, R. Gatenby, V. Cristini, An integrated computational/experimental model of tumor invasion[1]. Cancer Research 2006;66(3):1597-604. (http://math.uci.edu/~cristini/publications/Cancer%20Res%2006.pdf)

J2. V. Cristini, H. Frieboes, R. Gatenby, S. Caserta, M. Ferrari, J. Sinek, Morphological instability and cancer invasion. Clinical Cancer Research 2005;11(19):6772-9. (http://math.uci.edu/~cristini/publications/CCR%20Cristini.pdf)

J3. X. Zheng, S. Wise, V. Cristini, Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasion via an adaptive finite-element/level-set method[2]. Bulletin of Mathematical Biology 2005;67(2):211-59. (http://math.uci.edu/~cristini/publications/BullMathBiol05.pdf)

J4. J. Sinek, H. Frieboes, X. Zheng, V. Cristini, Two-dimensional chemotherapy simulations demonstrate fundamental transport and tumor response limitations involving nanoparticles[3]. Biomedical Microdevices 2004;6(4):297-309 (invited). (http://math.uci.edu/~cristini/publications/BMMD.pdf)

J5. V. Cristini, J. Lowengrub, Q. Nie, Nonlinear simulation of tumor growth[4]. J of Mathematical Biology 2003;46(3):191-224. (http://math.uci.edu/~cristini/publications/jmathbiol03.pdf)

Review Articles

J6. S. Sanga, J. Sinek, H. Frieboes, M. Ferrari, J. Fruehauf, V. Cristini, Mathematical modeling of cancer progression and response to chemotherapy: towards the development of a multiscale computer simulator. Expert Review of Anticancer Therapy 2006;6(10):1361-76. (invited) (http://math.uci.edu/~cristini/publications/cristini.pdf)

J7. S. J. Madsen, C.-H. Sun, B. J. Tromberg, V. Cristini, N. DeMagalhaes, H. Hirschberg, Multicell tumor spheroids in photodynamic therapy. Lasers in Surgery and Medicine 2006;38(5):555-64. (http://math.uci.edu/~cristini/publications/lasers.pdf)

Book Chapters

C1. S. Sanga, H. Frieboes, J. Sinek, V. Cristini, A multiscale approach for computational modeling of biobarriers to cancer chemotherapy via nanotechnology. In: Cancer Nanotechnology, eds: T. Webster, H. S. Nalwa; American Scientific Publishers 2006; Ch. 10, pp. 1-21 (invited). (http://math.uci.edu/~cristini/publications/Cncr-10.pdf)

C2. J. Sinek, H. Frieboes, B. Sivaraman, S. Sanga, V.Cristini, Mathematical and computational modeling: Towards the development and application of nanodevices for drug delivery. In: Series: Nanotechnologies for the Life Scences; Vol. 4: Nanodevices for the Life Sciences, ed: C Kumar; pp. 29-66; Wiley-VCH 2006 (invited). (http://math.uci.edu/~cristini/publications/kumar_4_c02.pdf)

C3. H. Frieboes, J. Sinek, O. Nalcioglu, J. Fruehauf, V. Cristini, Nanotechnology in cancer drug therapy: a biocomputational approach. In: BioMEMS and Biomedical Nanotechnology 2006; Vol. 1: Prospectus, Biological and Biomedical Nanotechnology, eds: A.P. Lee, L.J. Lee; Springer-Verlag; Ch. 15, pp. 435-460 (invited). (http://math.uci.edu/~cristini/publications/svus020-15-435-460.pdf)

BIOMEDICAL ENGINEERING (OTHER)

Journal Articles

J8. J. C. Y. Dunn, W. Y. Chan, V. Cristini, J. S. Kim, J. Lowengrub, S. Singh, B. M. Wu, Analysis of cell growth in three-dimensional scaffolds. Tissue Engineering 2006;12(4):705-16. (http://math.uci.edu/~cristini/publications/ten.2006.12.pdf)

Review Articles

J9. V. Cristini, G. S. Kassab, Computer modeling of red blood cell rheology in the microcirculation: A brief overview. Annals of Biomedical Engineering 2005;33(12):1724-7 (invited). (http://math.uci.edu/~cristini/publications/ABE05.pdf)

MICROFLUIDICS

Journal Articles

J10. V. Sibillo, G. Pasquariello, M. Simeone, V. Cristini, S. Guido, Drop deformation in microconfined shear flow. Physical Review Letters 2006; 97:054502. (http://math.uci.edu/~cristini/publications/prl.pdf)

J11. Y.-C. Tan, J. S. Fisher, A. I. Lee, V. Cristini, A.P. Lee, Design of Microfluidic Channel Geometries for the Control of Droplet Volume, Chemical Concentration, and Sorting[5]. Lab on a Chip 2004;4(4):292-8. (http://math.uci.edu/~cristini/publications/labchip04b.pdf)

J12. Y.-C. Tan, V. Cristini, A. P. Lee, Monodispersed microfluidic droplet generation by shear focusing microfluidic device. Sensors & Actuators B: Chemical 2006;114(1):350-6.

Review Articles

J13. V. Cristini, Y.-C. Tan, Theory and numerical simulation of droplet dynamics in complex flows-A review. Lab on a Chip 2004;4(4):257-64 (invited). (http://math.uci.edu/~cristini/publications/labchip04a.pdf)

COMPLEX FLUIDS

Journal Articles

J14. V. Cristini, J. Blawzdziewicz, M. Loewenberg, L. Collins, Breakup in stochastic Stokes flows: sub-Kolmogorov drops in isotropic turbulence. J. of Fluid Mechanics 2003;492:231-50.

J15. V. Cristini, S. Guido, A. Alfani, J. Blawzdziewicz, M. Loewenberg, Drop breakup and fragment size distribution in shear flow. J. of Rheology 2003;47(5):1283-98.

J16. J. Blawzdziewicz, V. Cristini, M. Loewenberg, Multiple stationary states for deformable drops in linear Stokes flows. Physics of Fluids 2003;15(5):L37-40.

J17. P. Patel, E. Shaqfeh, J. E. Butler, V. Cristini, J. Blawzdziewicz, M. Loewenberg, Drop breakup in the flow through fixed fiber beds: An experimental and computational investigation. Physics of Fluids 2003;15(5):1146-57.

J18. D. Khismatullin, Y. Renardy, V. Cristini, Inertia-induced breakup of highly viscous drops subjected to simple shear. Physics of Fluids 2003;15(5):1351-4.

J19. V. Cristini, R. Hooper, C.W. Macosko, M. Simeone, S. Guido, A numerical and experimental investigation of lamellar blend morphologies. Industrial & Engineering Chemistry Research 2002;41(25):6305-11.

J20. V. Cristini, C.W. Macosko, T. Jansseune, A note on transient stress calculation via numerical simulations. J. of Non-Newtonian Fluid Mechanics 2002;105(2-3):177-87.

J21. J. Blawzdziewicz, V. Cristini, M. Loewenberg, Critical behavior of drops in linear flows: I. Phenomenological theory for drop dynamics near critical stationary states. Physics of Fluids 2002;14(8):2709-18.

J22. V. Cristini, Flow-independent drop deformation with zero surface tension. Phys of Fluids 2002;14(8):2929-32.

J23. Y. Renardy, V. Cristini, J. Li, Drop fragment distributions under shear with inertia. International J. of Multiphase Flow 2002;28(7):1125-47.

J24. Y.Y. Renardy, M. Renardy, V. Cristini, A new volume-of-fluid formulation for surfactants and simulations of drop deformation under shear at a low viscosity ratio. European J. of Mechanics B/Fluids 2002;21(1):49-59.

J25. Y.Y. Renardy, V. Cristini, Scalings for fragments produced from drop breakup in shear flow with inertia. Physics of Fluids 2001;13(8):2161-4. (http://math.uci.edu/~cristini/publications/PoF01.pdf)

J26. Y.Y. Renardy, V. Cristini, Effect of inertia on drop breakup under shear. Physics of Fluids 2001;13(1):7-13. (http://math.uci.edu/~cristini/publications/PoF01b.pdf)

J27. J. Blawzdziewicz, V. Cristini, M. Loewenberg, Near-contact motion of surfactant-covered spherical drops: Ionic surfactants. J. of Colloid and Interface Science 1999;211(2):355-66. (http://math.uci.edu/~cristini/publications/JCIS99.pdf)

J28. J. Blawzdziewicz, V. Cristini, M. Loewenberg, Stokes flow in the presence of a planar interface covered with incompressible surfactant. Physics of Fluids 1999;11(2):251-8. (http://math.uci.edu/~cristini/publications/PoF99.pdf)

J29. V. Cristini, J. Blawzdziewicz, M. Loewenberg, Near-contact motion of surfactant-covered spherical drops. J. of Fluid Mechanics 1998;366:259-87. (http://math.uci.edu/~cristini/publications/JFM98.pdf)

J30. V. Cristini, J. Blawzdziewicz, M. Loewenberg, Drop breakup in three-dimensional viscous flows[6]. Physics of Fluids 1998;10(8):1781-3. (http://math.uci.edu/~cristini/publications/PoF98.pdf)

Review Articles

J31. V. Cristini, Y. Renardy, Scalings for droplet sizes in shear-driven breakup: non-microfluidic ways to monodisperse emulsions. Fluid Dynamics and Materials Processing 2006;2(2):77-94 (invited).

GROWTH OF MICROSTRUCTURE

Journal Articles

J32. S. Li, J. Lowengrub, P. Leo, V. Cristini, Nonlinear stability analysis of self-similar crystal growth: control of the Mullins-Sekerka Instability. J. of Crystal Growth 2005;277(1-4):578-92.

J33. S. Li, P. Leo, J. Lowengrub, V. Cristini, Nonlinear theory of self-similar crystal growth and melting. J. of Crystal Growth 2004;267(3-4):703-13.

J34. V. Cristini, J. Lowengrub, Three-dimensional crystal growth-II: Nonlinear simulation and control of the Mullins-Sekerka instability. J. of Crystal Growth 2004;266(4):552-67.

J35. X. Li, J. Lowengrub, Q. Nie, V. Cristini, P. Leo, Microstructure evolution in three-dimensional inhomogeneous elastic media. Metallurgical and Materials Transactions A 2003;34A(7):1421-31.

J36. V. Cristini, J. Lowengrub, Three-dimensional crystal growth-I: linear analysis and self-similar evolution. J. of Crystal Growth 2002;240(1-2):267-76.

NUMERICAL METHODS

Journal Articles

J37. X. Yang, A. J. James, J. Lowengrub, X. Zheng, V.Cristini, An adaptive coupled level-set/volume-of-fluid interface capturing method for unstructured triangular grids. J. of Computational Physics 2006;217(2): 364-394.

J38. F. Xie, P. Sheu, A. Lander, V. Cristini, Semantic Analysis and Synthesis of Complex Biological Systems. International J. of Software Engineering and Knowledge Engineering 2005;15(3):547-69.

J39. A. Anderson, X. Zheng, V. Cristini, Adaptive unstructured volume remeshing-I: The method. J. of Computational Physics 2005;208(2):616-25. (http://math.uci.edu/~cristini/publications/jcp05a.pdf)

J40. X. Zheng, J. Lowengrub, A. Anderson, V. Cristini, Adaptive unstructured volume remeshing-II: Application to two- and three-dimensional level-set simulations of multiphase flow. J. of Computational Phys 2005;208(2):626-50. (http://math.uci.edu/~cristini/publications/jcp05b.pdf)

J41. V. Cristini, J. Blawzdziewicz, M. Loewenberg, An adaptive mesh algorithm for evolving surfaces: simulations of drop breakup and coalescence[7]. J. of Computational Physics 2001;168(2):445-63. (http://math.uci.edu/~cristini/publications/JCompPhys01.pdf)

OTHER

Journal Articles

J42. M. Ferrari, L. Anzidei, V. Cristini, G. Simbolotti, Impact of the passive stabilization system on the dynamic loads of the ITER first-wall/blanket during a plasma disruption event. Fusion Eng and Design 1995;27:507-14.

TEACHING

· Applied Eng Math II—Numerical Analysis (Biomedical Engineering, U. C. Irvine, 2003-2006, graduate)

· Bio-Mass transport (Biomedical Engineering, U. C. Irvine, 2004-2006, undergraduate)

· Introduction to predictive oncology (Biomedical Engineering, U. C. Irvine, 2005-2006, graduate)

· Math modeling and computer simulation of complex biol systems (Biomed Eng, U. C. I. 2003-4, graduate)

· Intro to Math and Computational Biol (COSMOS Program Physical Sciences, U. C. I. 2004-5, high school)

· Virtual Cancer: A Computer Model of Cancer Progression and Treatment (Eng, UCI 2003, Freshman Sem)

· Calculus I (School of Mathematics, U. of Minnesota, 2002, undergraduate)

· Transport Phenomena (Chemical Engineering and Materials Science, U. of Minnesota, 2000, undergraduate)

CONFERENCE ORGANIZATION ROLES

· Session Chair, International Biofluid Mechanics Conference, Caltech 2003.

· Program Committee Member, 4^th IEEE Internat Symp on Bioinformatics and Bioeng, Taichung, Taiwan 2004.

· Program Committee Member, Dynamics Days 2005, UC Irvine.

· Session Chair, Dynamics Days 2005, UC Irvine.

· Session Chair, Stability and Non-linear Hydrodynamics, Am Inst of Chem Engineers Annual Meeting 2005.

· European Conference on Mathemat and Theoret Biol (ECMTB) 2005, editor of the conference proceedings

· Program Committee Member, Internat Brain Mapping and Intra-operative Surgical Planning Symp 2005-7.

· Session Chair, Internat Brain Mapping and Intra-operative Surgical Planning Symposium (USC) 2005-2006.

· Program Committee Member, Inst for Pure and Applied Math, UCLA, Cells and Materials conf. 2006.

· Session Chair, "Cells and Materials: At the Interface between Mathematics, Biology and Engineering," Microfluidics symposium, Institute for Pure and Applied Mathematics, UCLA 2006.

· 15^th US National Congr Theoret Appl Mech (USNCTAM06), U of Colorado, Boulder 2006, Biomech of Tissues Mini-symposium

FUNDING AGENCIES SERVICE

· Reviewer, Dept of Energy-Office of Science 03. Progr: Innovative and Novel Computational Impact on Theory and Experiments.

· Reviewer, Department of Energy-Office of Science, 2005. Program: Basic Energy Sciences.

· Reviewer, National Science Foundation-Division of Mathematical Sciences, 2005.

· Panel member, Telemedicine and Advanced Technology Research Command (TATRC)/American Institute of Biological Sciences (AIBS) panel to conduct independent scientific review to the Alliance for NanoHealth (ANH) program. Houston, TX 06.

· Reviewer, Medical Research Council, UK

INVITED LECTURES (MOST RELEVANT)

[1] Cancer Research Highlights, Feb 1 2006: “Simulation model predicts tumor invasion in marginal environmental conditions.”

[2] New Hot Paper in the field of Mathematics, July, 2006, Thomson-Scientific Essential Science Indicators. Also, Most cited article, Bulletin of Mathematical Biology 2005-present.

[3] Also published as abstract: Cristini, J. of Clinical Oncology 2005;23(16):163s.

[4] Most cited article, J of Mathematical Biology 2003-present.

[5] Top 0.7 percentile of citations, Lab on a Chip 2004-present

[6] Top 0.5 percentile of citations, Physics of Fluids 1998-present.

[7] Top 0.4 percentile of citations, J. of Computational Physics 2001-present.